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Polyurethanes blood compatibility enhancement

Early attempts to functionalize biomaterial surfaces with biological molecules were focused on improving blood compatibility of cardiovascular devices, such as the artificial heart and synthetic blood vessels, by immobilizing heparin or albumin on polyurethane or Dacron . To enhance cell adhesion to biomaterial surfaces, entire extracellular matrix (ECM) proteins, such as fibronectin and laminin, have been used directly as coatings. However, because of the nonspecific manner of whole protein adsorption, most of the cell binding capability is often lost. Using a molecular templating technique, it may be possible to select which protein(s) to absorb on biomaterial surfaces. ... [Pg.1100]

Negative Cilia Concept for Enhanced Blood Compatibility Grafting of PEO-Sulfonate onto Polyurethane... [Pg.4]

Yuan, J., Lin, S., Shen, J. Enhanced blood compatibility of polyurethane functionalized with sulfobetaine. CoUoids Surf. B Biointerfaces 66(1), 90-95 (2008)... [Pg.505]

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Blood compatibility

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