Polytopic Interactions Change of Binding Mechanism with Different Fit

Di- and Polytopic Interactions Change of Binding Mechanism with Different Fit 

The performance of ditopic receptors will suffer if the spacer is not long and/or flexible enough to allow simultaneous full contact at all binding centers. In some cases one observes only weakening of affinities [41], while in other cases one of the possible intermolecular forces cannot materiahze at all. Thus, additive ion pairing as well as dispersive interactions with positively charged polyaromatic host compounds are present, e.g., in complexes of AMP with tetrapyridinium porphy- 

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