Polyribonucleotides, single-stranded

Melvin T, Botchway SW, Parker AW, O Neill O (1996) Induction of strand breaks in single-stranded polyribonucleotides and DNA by photoionization one electron oxidized nudeobase radicals as precursors. J Am Chem Soc 118 10031-10036... 

In order to give DNA immunizing properties Plescia et al. (1964, 1965) complexed the material to MBS A. A certain number of polynucleotides such as denatured DNA, poly dAT, and tRNA associated with MBS A have been used as immunogens by these authors. This method of preparation has been used for other polynucleotides, particularly for single-stranded synthetic polynucleotides and the various double- and triple-hehcal complexes formed from such polyribonucleotides. It appears that secondary structure of these complexes is generally maintained on adsorption onto MBS A, although some of their characteristics could well be modified in this electrostatic interaction. 

Free DDA concentration (x10 ) M Figure 10.2 Binding isotherms of DDA with native (1) and denatured (2) DNA, with single-stranded polyribonucleotides poly (U) (3), poly(A) (5), as well as with double helix poly(U) poly(A) (4). (From Ref. [10].)... 

Bustamante C, Gurrieri S, Pasternack RF et al (1994) Interaction of water-soluble porphyrins with single- and double-stranded polyribonucleotides. Biopolymers 34 1099-1104... 

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