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Polyprenyl Isoprenoid Compounds

It is also a precursor for synthesis of polyprenyl (isoprenoid) compounds, and it can give rise to free acetoacetate, an important constituent of blood. Acetoacetate is a (3-oxoacid that can undergo decarboxylation to acetone or can be reduced by an NADH-dependent dehydrogenase to D-3-hydroxybutyrate. Notice that the configuration of this compound is opposite to that of L-3-hydroxybutyryl-CoA which is... [Pg.946]

The second five-carbon branched unit, in which the branch is one carbon further down the chain, is an intermediate in the biosynthesis of polyprenyl (isoprenoid) compounds and steroids. Three two-carbon units are used as the starting material with decarboxylation of one unit. Two acetyl units are first condensed to form acetoacetyl-CoA. Then a third acetyl unit, which has been transferred from acetyl-CoA onto an SH group of the enzyme, is combined with the acetoacetyl-CoA through an ester condensation. The thioester linkage to the enzyme is hydrolyzed to free the product 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). This sequence is illustrated in Eq. 17-5. The thioester group of HMG-CoA is reduced to the... [Pg.992]

See other pages where Polyprenyl Isoprenoid Compounds is mentioned: [Pg.1226]    [Pg.1227]    [Pg.1228]    [Pg.1230]    [Pg.1232]    [Pg.1234]    [Pg.1236]    [Pg.1238]    [Pg.1240]    [Pg.1242]    [Pg.1244]    [Pg.1246]    [Pg.1248]    [Pg.1250]    [Pg.1252]    [Pg.1254]    [Pg.1256]    [Pg.1258]    [Pg.1260]    [Pg.1262]    [Pg.1264]    [Pg.1266]    [Pg.1268]    [Pg.1270]    [Pg.313]    [Pg.314]    [Pg.315]    [Pg.317]    [Pg.319]    [Pg.321]    [Pg.323]    [Pg.325]    [Pg.327]    [Pg.329]    [Pg.331]    [Pg.333]    [Pg.337]    [Pg.343]    [Pg.345]    [Pg.347]    [Pg.349]    [Pg.355]   


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Isoprenoid compounds

Isoprenoids

Polyprenyl compounds

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