Polyphosphoesters applications

Polyphosphoesters are a novel class of polymers being studied for applications in drug delivery and tissue engineering (Fig. 6). The individual components can be... 

Chapter 9 by Wentrup-Byrne et al. reports on the biomedical applications of phosphorus-containing polymers such as poly[2-(aciyloylo g )ethyl phosphate], poly[2-(methacryloylo Q )ethyl phosphate], and polyphosphoesters, especially tissue repair and regeneration, medical device development, and tissue engineering. A broad overview is achieved, as applications considered include cardiovascular, ophthalmological, drug and gene deliveiy, as well as orthopedics and bone-interface repair, their surface chemistiy, and the subsequent biomineralization proeesses. 

A useful review covering polyphosphoester (PPE) synthesis and biomedical applications appeared in 2009. However, a word of caution some of the... 

A plethora of bioresorbable polymer materials are adopted for medical and pharmaceutical applications. Among them, aliphatic polyesters, polycarbonates, poly (amino acids), and polyphosphoesters are the main representatives. For the synthesis of NPs, aliphatic polyesters are the most adopted materials. Data on a huge number of different polyesters can be found in the literature, but this chapter focuses on the main polyesters poly (lactic acid) (PLA), poly(glycolic acid) (PGA), polycaprolactone (PCL), and their copolymers [4]. 

Figure 2.1 Basic structures for some groups of synthetic polymers commonly employed as degradable materials in medical applications a) polylactide-co-polyglycolides (also commonly used as their homopolymers (i.e., n/m = 0), b) polycaprolactones, c) polydioxanones, d) polyorthoesters, e) polyanhydrides, f) polyalkylcyanoacrylates, g) poly(organo)phosphazenes and h) polyphosphoesters...

Polyphosphoesters Controlled Ring-Opening Polymerization and Biological Applications... 

Polyphosphoesters Controlled Ring-Opening Poiymerization and Bioiogical Applications 723... 

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