Polyphosphate in Bioenergetics of Eukaryotes

the synthesis of ATP from PolyP has been observed in isolated vacuoles of yeast (Schabalin etal, 1977). However, the significance of this process needs further investigation. 

Thirdly, observations of the PolyP dynamics during the growth of S. cerevisiae give additional indirect evidence of PolyP participation in the processes of energy conservation in 

Furthermore, in an adenine-deficient mutant of N. crassa, where the concentrations of ATP and other adenyl nucleotides are sharply reduced, PolyP is alternatively synthesized during glycolytic phosphorylation by l,3-diphosphoglicerate PolyP phosphotransferase (Kulaev and Bobyk, 1971). Thus, under certain conditions PolyP can replace ATP as an energy reserve in eukaryotes. 

PolyPs of 12-25 P residues were found in the mitochondria of. S, cerevisiae (Beauvoit et al., 1989). The amounts increase sharply under phosphate overplus (Pestov et al., 2003). The function of PolyPs in mitochondria needs further investigation. PolyPs also occur 

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