Polypeptides oligomers synthesis

This equation is not intended to imply a mechanism for peptide synthesis. The equilibrium position for this reaction in an aqueous solution favors the free amino acids rather than the peptide. Therefore, both biological and laboratory syntheses of peptides usually do not involve a simple splitting out of water. Since the dipeptide of Eq. 2-11 still contains reactive carboxyl and amino groups, other amino acid units can be joined by additional peptide linkages to form polypeptides. These range from short-chain oligomers to polymers of from 50 to several thousand amino acid units, the proteins.75-77... 

In the literature a majority of the publications involving enzyme-catalyzed synthesis of polypeptides and polyamides use proteases and related proteolytic enzymes. The data indicate that proteases are good catalysts for the synthesis of oligomers. For high-molecular-weight polymers, the use of protease is more difficult and less reported. 

Kablov, V. F. Kondmtsky, D. A. Sudnitsina, M V. Synthesis and properties of phosphorus-containing polypeptides for effective ion-exchange materials of improved capacity, In Progress in Monomers, Oligomers, Polymers, Composites and Nanocomposites, Nova Science Publishers New York 2009 pp. 113-123. 

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