Polymorphism pattern recognition method

Aldridge et al. [42] used pattern recognition to differentiate between the desired and unwanted polymorphs of an active substance. More importantly, the method was transferred to at least six other instruments for application. 

Aldridge et al. [62] used pattern recognition to differentiate between the desired and unwanted polymorphs of an active substance. More importantly, the method was transferred to at least six other instruments for application. Polymorphism of drug substances was studied by De Braekeleer et al. [63] in 1998. They used PCA, SIMPLISMA, and orthogonal projections to correct for temperature variation during the monitoring of polymorph conversion. This was performed in real time, online in a commercial process. 

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