Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Polymorphic transformations particle size reduction

Polymorphic transformation can take place during pharmaceutical processing, such as particle size reduction, wet granulation, drying, and even during the compaction process.f Tests employed to determine crystal... [Pg.3642]

Tablets and other drug formulations often comprise the active pharmaceutical ingredient (API) and pharmacologically inert carrier substances, or excipients, which bind, stabilize, and assist absorption of the drug by the body, or simply add bulk to APIs in low dosages. Common excipients are inorganic phosphates and organic compounds such as lactose, cellulose, and polyethylene glycol. Particle size reduction by micronization or milling can provide the energy to transform an API into undesirable polymorphs or... Tablets and other drug formulations often comprise the active pharmaceutical ingredient (API) and pharmacologically inert carrier substances, or excipients, which bind, stabilize, and assist absorption of the drug by the body, or simply add bulk to APIs in low dosages. Common excipients are inorganic phosphates and organic compounds such as lactose, cellulose, and polyethylene glycol. Particle size reduction by micronization or milling can provide the energy to transform an API into undesirable polymorphs or...
See other pages where Polymorphic transformations particle size reduction is mentioned: [Pg.84]    [Pg.547]    [Pg.948]    [Pg.149]    [Pg.20]    [Pg.82]    [Pg.302]    [Pg.345]    [Pg.65]    [Pg.368]    [Pg.413]   
See also in sourсe #XX -- [ Pg.3642 ]



SEARCH



Particle size reduction

Particles reduction

Polymorphic transformations

Size reduction

© 2024 chempedia.info