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Polymers SMANCS

SMANCS (Styrere-co-maleic acid/anhydride polymer bound to neocarzinostatin Neocarzinostatin (an antitumor protein) Amide bond between polymer carboxyl and protein amino None N/A SMANCS showed anticancer activity against many tumor cell lines, and had lower IC50 values than five other anticancer agents tested Liver tumors reduced more than 50% after 6 months in human subjects 15, 56, 57... [Pg.68]

Maeda H. SMANCS and polymer-conjugated macromolecular drugs advantages in cancer chemotherapy. Adv Drug Deliv Rev 1991 6 181-202. [Pg.384]

Maeda H, Matsumoto T, Konno T, Iwai K, Ueda M. Tailor-making of protein drugs by polymer conjugation for tumor targeting A brief review on smancs. J Protein Chem 1984 ... [Pg.117]

Maeda H, Takeshita J, Kanamaru R (1979) A lipophilic dtaivative of neocarzinostatin a polymer conjugation of an antitumor protein antibiotic. Int J Pept Protein Res 14 81-87 Maeda H (1991) SMANCS and polymer-conjugated macromol ocular drugs advantages in cancer chemotherapy. Adv Drug Deliv Rev 46 169-185... [Pg.259]

T. Oda, F. Sato, and H. Maeda, Facilitated internalization of neocarzinostatin and its hpo-philic polymer conjugate, SMANCS, into cytosol in acidic pH, /. Nat. Cancer Inst., 79 (6), 1205-1211,1987. [Pg.301]

F. Suzuki, T. Munakata, and H. Maeda, Interferon induction by SMANCS Polymer conjugated derivative of neocarcinostatin. Anticancer Res., 8,97-104,1988. [Pg.301]

F. Suzuki, R.B. Pollard, S. Uchimura, T. Munakata, and H. Maeda, Role of natural killer cells and macrophages in the nonspecific resistence to tumors in mice stimulated with SMANCS, a polymer-conjugate derivative of neocarzinostatin. Cancer Res., 50 (13), 3897-3904,1990. [Pg.301]

Examples of clinically validated water-insoluble, biodegradable polymers include material such as poly(D,L,lactide-c< -glycolide (PLGA) poly(ortho esters) (POE) and polyisohexylcyanoacrylate (PIHCA) These materials have been used for the preparation of nanoparticles, biodegradable implants and viscous injectable materials. In addition, one amphiphilic material, poly(styrene-co-maleic acid) copolymer conjugated with neocarzinostatin (SMANCS) dissolved in lipid contrast medium Lipiodol, has proven efficacious in several clinical tri s for the treatment of cancer... [Pg.3]

Modification of hydrophilic proteins with hydrophobic polymers has been also explored as a way to enhance protein transport into a cell. For example, conjugation of a small water-soluble peptide neocarzinostatin, with poly(styrene-co-maleic acid) copolymer (SMANCS) resulted in a 20 to 30 fold enhancement ofthe transport ofthe peptide into a cell. This polymer conjugate also displayed facilitated uptake into cells at acidic pH, which may be due to protonation of carboxylic groups of the polymer chain rendering it even more hydrophobic. Since more acidic environment is... [Pg.12]

Figure 2. A. Intratumor accumulation of various Cr-tagged proteins in solid tumor-bearing mice o, neocarzinostatin (NCS) (12 kDa) , SMANCS (16 kDa, but known to bind to albumin) , ovomucoid (29 kDa) , bovine serum albumin (69kOa) , mouse serum albumin (68 kDa) , mouse immunoglobulin G (160 kDa). Radiolabeled proteins were injected i.v. at time zero. Values are based on radioactivity (cf. Fig. 2). The tumor model in both A and B was solid sarcoma S-180 in mice. (From ref. 26, with permission). B. Relationship of drug distribution and molecular size to plasma concentration, AUC (area under the concentration curve), renal clearance, and intratumor uptake as expressed by percentage of injected dose. Putative polymer drugs are 1-Tyr-HPMA-copolymers of various molecular sizes given i.v. at 1.8 xlO cpm. The tumor model was sarcoma S-180 in mice. (From ref. 28 with permission). Figure 2. A. Intratumor accumulation of various Cr-tagged proteins in solid tumor-bearing mice o, neocarzinostatin (NCS) (12 kDa) , SMANCS (16 kDa, but known to bind to albumin) , ovomucoid (29 kDa) , bovine serum albumin (69kOa) , mouse serum albumin (68 kDa) , mouse immunoglobulin G (160 kDa). Radiolabeled proteins were injected i.v. at time zero. Values are based on radioactivity (cf. Fig. 2). The tumor model in both A and B was solid sarcoma S-180 in mice. (From ref. 26, with permission). B. Relationship of drug distribution and molecular size to plasma concentration, AUC (area under the concentration curve), renal clearance, and intratumor uptake as expressed by percentage of injected dose. Putative polymer drugs are 1-Tyr-HPMA-copolymers of various molecular sizes given i.v. at 1.8 xlO cpm. The tumor model was sarcoma S-180 in mice. (From ref. 28 with permission).
Maeda, H., and Konno, T., 1997, Metamorphosis of neocarzinostatin to SMANCS chemistry, biology, pharmacology and chnical effect of the first prototype anticancer polymer therapeutic. In Neocarzinostatin The Past, Present, and Euture of an Anticancer Drug (H. MAEDA, K. EDO and N. ISHIDA, eds.) Springer-Verlag, Tokyo, Berlin, New York, pp. 227-267. [Pg.49]

See other pages where Polymers SMANCS is mentioned: [Pg.6]    [Pg.219]    [Pg.146]    [Pg.349]    [Pg.123]    [Pg.136]    [Pg.99]    [Pg.266]    [Pg.142]    [Pg.9]    [Pg.185]    [Pg.8]    [Pg.50]    [Pg.252]    [Pg.17]    [Pg.111]    [Pg.112]    [Pg.230]    [Pg.281]    [Pg.287]    [Pg.32]    [Pg.230]    [Pg.7]    [Pg.17]    [Pg.111]    [Pg.112]    [Pg.4]   
See also in sourсe #XX -- [ Pg.5 , Pg.15 , Pg.219 ]



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