Polymer post-modification coupling reactions

Huisgen 1,3-dipolar cycloaddition (click reaction) between terminal alkynes and azides is a highly efficient approach for the post modification of polymers. This technique is tolerant to a wide rage of reaction conditions and functional groups allowing fast coupling reactions under simple reaction conditions with... 

Abstract The Biginelli reaction, a three-component cyclocondensation reaction, is an important member of the multicomponent reaction (MCR) family. The Biginelli reaction is so efficient and shares many similar properties as the recent click reactions. In this chapter, we summarised the current applications of the Biginelli reaction in polymer chemistry including polymer coupling, post polymer modification, and new functional polymer synthesis. We expect this old reaction (>120 years) can draw attention from polymer chemists and play new roles in the polymer science. 

Post-polymerization modification of reactive polymer films provides the possibility to design complex coatings associated with intricate structure and morphology [1, 4, 97, 98]. Using a simple procedure, two or more types of chemical functionalities can be applied onto substrates that are contained in covalently grafted polymer films. Multifunctional surfaces can be fabricated by sequential click reactions or simultaneous multiple click reactions in one-pot. Click-like reactions such as thiol-based additions, activated ester coupling, and azide-alkyne cycloadditions are those most used for post-polymerization modification, because these reactions yield orthogonal reactive polymer brushes rapidly and quantitatively [17]. 

---