Polymer Architectures Employing Enzymatic ROP

4 Polymer Architectures Employing Enzymatic ROP 391 graft copolymers 

Enzymatic ROP has also been successfully combined with chemically catalyzed polymerization methods in SCCO2, allowing the formation of block structures. For example, Howdle and coworkers reported a simultaneous use of Novozym 435 with metal atalyzed ATRP that allowed the formation of block copolymers of PCL and PMMA [107, 108], whilst a two-step methodology was used to form block copolymers of PCL with poly(fluoro-octyl methacrylates) (PFOMA) [109]. Similar reactions, simultaneously combining reversible addition-fragmentation chain transfer (RAFT) with enzymatic ROP to form block copolymers of polystyrene and PCL, have also been performed in SCCO2 [110]. Block copolymer synthesis in SCCO2 has recently been reviewed [111]. 

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