Polymastia boletiformis

Polymastiamide A (579), an antimicrobial steroid with an unusual side chain modification involving an amide bond to a non-protein amino acid, was isolated from the Norwegian marine sponge Polymastia boletiformis. The structure of polymastiamide A (579) was elucidated by analysis of spectroscopic data and chemical interconversions [470]. Polymastiamides B-F (580-584), additional amino acid conjugates of steroids, were later isolated from the same sponge [471],... 

Additional unusual steroid derivatives have been isolated from marine sponges, eg., polymastiamides, steroid/aminoacid conjugates isolated from Polymastia boletiformis, a Norwegian marine sponge [180], and an aminoimidazolium salt of steroid trisulfate from Topsentia sp. [181], Some of these marine sterols are being reproduced by chemical synthesis in the laboratory [182],... 

Kong, F. and Andersen, R.J. (1993) Polymastiamide A, a novel steroid/ aminoacid conjugate isolated from the Norwegian marine sponge Polymastia boletiformis (Lamarck, 1815). J. Org. Chem., 58, 6924-6927. 

---

See also in sourсe #XX -- [ , , ]

---