Polyleucine oxidation

Some of the practicals describe the use of similar catalysts and/or catalysts that accomplish the same task. This has been done purposely to try to get the best match between the substrate described and the one being considered by an interested reader. Moreover when catalysts can be compared, this has been done. Sometimes a guide is given as to what we found to be the most useful system in our hands. In this context, it is important to note that, except for polyleucine-catalysed oxidations and the use of a bicyclic bisphosphinite for asymmetric hydrogenation, the Liverpool group had no previous experience in... 

In determining the diversity of reactions which may be catalysed by polyleucine, it has been shown that the oxidation of sulfides to sulfoxides can be performed, achieving excellent levels of asymmetric induction. Thus, when polyleucine is coated onto a platinum electrode, oxidation of sulfides to optically active sulfoxides has been achieved in 77% e.e. and 56% yield, (Scheme 11) [22]... 

Since the polyleucine epoxidation conditions are only favourable for highly electron-deficient unsaturated systems (i. e. ketones), use of the Baeyer-Villiger oxidation subsequent to the epoxidation reaction allows access to the optically active epoxyesters. 

REGIO- AND STEREO-CONTROLLED OXIDATIONS AND REDUCTIONS 6.11.1 PREPARATION OF POLYLEUCINE-HYDROGEN PEROXIDE GEL... 

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