Polylactosaminoglycans chains

Figure 10. Cooperative action of a3-NeuAcT (a3-ST, dashed arrow), a3-FucT IV (myeloid enzyme a3-FT, thin solid arrow), and a3-FucT VII (a3-FT, leukocyte enzyme bold solid arrow) in the synthesis of sialyl-oligomeric Lewis and related structures on polylactosaminoglycan chains. F, Fuc G, Gal GN, GlcNAc LAG, polylactosaminoglycan SA, NeuAc.

Another specific modification of polylactosaminoglycan chains is the introduction of a3-Fuc residues to non-terminal GlcNAcs along the chain to yield a (sialyl-) oligomeric-Lewis structure. In leukocytes the formation of this structure, which is a ligand for E- and P-selectin, is catalyzed by two different a3-FucTs, the myeloid FucT (FucT IV) and the leukocyte FucT (FucT VII) [92, 93] (Figure 10) (see also Section 23.20, o314-Fucosyltransferase Family below). 

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