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Polyketide plant defensive compounds

PKSs are characterized by their ability to catalyze the formation of polyketide chains from the sequential condensation of acetate units from malonate thioesters. In plants they produce a range of natural products with varied in vivo and pharmacological properties. PKSs of particular note include acridone synthase, bibenzyl synthase, 2-pyrone synthase, and stilbene synthase (STS). STS forms resveratrol, a plant defense compound of much interest with regard to human health. STS shares high sequence identity with CHS, and is considered to have evolved from CHS more than once. ° Knowledge of the molecular structure of the CHS-like enzymes has allowed direct engineering of CHS and STS to alter their catalytic activities, including the number of condensations carried out (reviewed in Refs. 46, 51, 52). These reviews also present extensive, and superbly illustrated, discussions of CHS enzyme structure and reaction mechanism. [Pg.155]

Figure 21-10 Some important polyketide antibiotics and plant defensive compounds. Figure 21-10 Some important polyketide antibiotics and plant defensive compounds.
In most cases of secondary protection of insect herbivores by alkaloids the source of the alkaloid is the herbivore diet, i.e. the plant host. There have been several interesting reports on the occurrence of chemical defenses of insects based on alkaloids actively synthesized or at least chemically modified by the insect. One such report showed that deterrence to predation by ants and spiders was afibrded to the Mexican bean beetle Epilachna varivestis) by the production of the homotropane alkaloid euphococcinine (66). This compound which actually may be a polyketide, is not present in the body of larvae or newly hatched adults but is accumulated in the beetles blood within one week of emergence. When attacked, the beetle reflex-bleeds emitting droplets of blood containing as much as 5 pg of euphococcinine. [Pg.162]


See other pages where Polyketide plant defensive compounds is mentioned: [Pg.27]    [Pg.240]    [Pg.5]    [Pg.70]    [Pg.84]    [Pg.479]    [Pg.85]    [Pg.129]   
See also in sourсe #XX -- [ Pg.1216 ]




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