Polyketide anticancer antibiotic biosynthesis

Reactions of the Benzene Ring of Phenols 953 THE CHEMISTRY OF... Polyketide Anticancer Antibiotic Biosynthesis 954... 

Polyketide Anticancer Antibiotic Biosynthesis 954 The Bombardier Beetle s Noxious Spray 958 Bacterial Dehalogenation of a PCB Derivative 961... 

One new wrinkle on the combinatorial strategy involves a process referred to as combinatorial biosynthesis. In this situation, bacterial gene expression is altered in the hope of changing the structure and function of specific enzymes. For example, one class of potential bacteria-derived drugs are the polyketides, which may have antibiotic, immunosuppressant, and anticancer activity. Bacteria produce polyketides with the help of a family of enzymes known as polyketide synthases (PKSs). To date, most of the normally produced polyketides screened have shown little activity. 

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