Polyether antibiotics occurrence

The widespread occurrence and biological significance of the macrolide ansamycin and polyether antibiotics, and of polyhydroxylated natural products, including rare carbohydrates, among others, has stimulated considerable interest in the development of concise, efficient synthetic methodology for the stereo-and enantio-selective construction of stereochemically adorned acyclic molecules.Indeed, considerable effort has been devoted towards the development of highly stereoselective syntheses of the so-called propionate (e.g.—CHMe—CHOH—CHMe—CHOH—), acetate (c.g.—CHOH—CH2CHOH—CH —)... 

The occurrence of highly functionalized furanoid systems either as a key entity or key substructure of more complex molecules in various biologically active natural products, such as the entire class of polyether antibiotics, prostaglandins, prostacyclins, and marine Laurencia metabolites, initiated new developments in their syntheses. 

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