Polyene hydroxyl-substituted

The complex polyene hydroxyl-substituted tetrahydrofuran metabolite ( )-citreoviral was synthesized by G. Pattenden and co-workers." All four carbons on the tetrahydrofuran ring are chiral, and in the final stages of the synthetic effort the stereochemistry of the C3 secondary homoallylic alcohol had to be inverted. This step was best achieved by a Moffatt ox/daf/on/NaBH4 reduction sequence. 

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