Polydentate Ligands Containing 1,4-Disubstituted

It is clear that the CuAAC click reaction can be exploited to rapidly synthesize families of functionalized ligand architectures, and this synthetic versatility could lead to many potential applications. However, before the full potential of these click ligands can be realized, an understanding of the coordination properties of 1,4-disubstituted-l,2,3-triazoles is required. In the following sections, we will examine the coordination properties of monodentate, bidentate, tridentate, and polydentate ligands containing 1,4-disubstituted-l,2,3-triazole units. 

Polydentate Ligands Containing 1,4-Disubstituted-l,2,3-Triazole Units... 

Polydentate Ligands Containing One 1,4-Disubstituted-1,2,3-Triazole Unit... 

There have been many polydentate ligands reported which contain a single 1,4-disubstituted-1,2-3-triazole imit, but for the most part, these have been synthesized to be metal ion sensors and, as such, will not be discussed further [203-209]. 

In coordination chemistry, architectures containing the triazole heterocycle have been developed as monodentate and polydentate nitrogen ligands. Special attention has been given to (2-pyridyl)- and more flexible (2-picolyl)-l,2,3-triazoles. Thus, a hbrary of selected 1,4-disubstituted 1,2,3-triazoles differently functionahzed with pyridine, pyrimidine, and pyrazine have been synthesized by the reaction of aryl, heteroaryl, and heteroarylmethyl azides with alkynes. Three different copper(l) sources, that is, CuSO /sodium ascorbate, CuBrlPPhglg, and (CuOTf)2 CgHg, were used to promote the reactions [89]. 

---