Polycyclic fjord region

Melendez-Colon, V. J., Luch, A., Seidel, A., and Baird, W. M. (2000). Eormation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures. Chem Res Toxicol 13, 10-17. 

Buterin, T., Hess, M.T., Luneva, N., Geadntov, N.E., Amin, S., Kroth, H., Seidel, A., and Naegeli, H. (2000) Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adduds in ras codon 61 mutational hot spots. 

In summary, our hypothesis is that the increased polycyclic aromatic ring-base stacking interactions in the fjord region PAH diol epoxide-N -dA adducts stabilize the duplexes and inhibit the extent of strand opening in XPC/HR23B complexes that is critically important for successful NER [38], possibly by preventing the flipping out of nucleotides from the complementary strand. 

Phillips DH, Hewer A, Seidel A, et al. 1991. Relationship between mutagenicity and DNA adduct formation in mammalian cells for fjord- and bay-region diol-epoxides of polycyclic aromatic hydrocarbons. Chem Biol Interact 1991 80(2) 177-186. 

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