Polycitor africanus, polycitone

Decatromicins A (1218) and B (1219) are produced by an Actinomadura sp. and are active against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (1229,1230). These compounds are closely related to pyrrolosporin A (1220) from Micromonospora sp. (1231,1232). The ascidian Polycitor africanus from Madagascar has afforded the new polycitone B (1221) (1233), which is related to the known polycitone A (1), a potent inhibitor of retroviral reverse transcriptases and cellular DNA polymerases (1234). The known polycitrin B was synthesized for the first time (1235). 

Rudi A, Evan T, Aknin M, Kashman Y (2000) Polycitone B and Prepolycitrin A Two Novel Alkaloids from the Marine Ascidian Polycitor africanus. J Nat Prod 63 832... 

Rudi, A., Evan, T., Aknin, M., Kaslunan, Y., (2000). Polycitone B and Prepolycitrin A Two novel alkaloids from the marine ascidian Polycitor africanus. J. Nat. Prod. 63, 832-833. 

Polycitone A (280) and B (281), polycitrin A (282) and B (283), and prepolycitrin A (284) were reported from the Indo-Pacific ascidians Polycitor sp. and P. africanus by Kashman s group (167,168). Their structures were established by spectroscopic and chemical methods. The structure of polycitone A (280) was confirmed by X-ray crystallography (167). 

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