Poly vascular prostheses

In a more recent paper [160], Urry et al. reported that x20-poly (GGAP) was nonadhesive to both bovine ligamentum nuchae fibroblast and human umbilical vein endothelial cells (HUVECs), even in the presence of serum. Urry et al. interpreted this behavior in terms of their hydrophobicity scale. They suggested that x20-poly[50(GGAP), (GRGDSP)], for example, could provide the inner lamina for a vascular prosthesis. 

Mrowczynski, W., Mugnai, D., de Valence, S, Tille, J.C., Khabiri, E., Cikirikcioglu, M. et al. (2013) Porcine carotid artery replacement with biodegradable electrospun poly-e-caprolactone vascular prosthesis. J. Vase. Surg., 59 (1), 210-219. 

By copolymerizing the monomers of two highly crystalline homopolymers it is possible to create a series of less crystalline copolymers with reduced levels of stiffness, elastic modulus and crystallinity depending on the blend level of the two monomers. This has been demonstrated by Soo H5nm Kim and coworkers at KIST, who have been able to synthesize a series of elastomeric (or rubbery) resorbable poly(L-lactide-co-e-caprolactone) copolymers. Because of their superior elastic behavior they have been used to prepare tubular scaffolds for vascular smooth muscle cell (SMC) culture under dynamic pulsatile conditions. We have melt spun and electrospun the 50/50 copolymer to fabricate a two-layer small-caliber vascular prosthesis prototype with radial elongation at break in excess of 300% (Fig. 15.33). " ... 

Yoneyama T, Ishihara K, Nakabayashi N, Ito M, Mishima Y. Short-term in vivo evaluation of small-diameter vascular prosthesis composed of segmented poly(etherure-thane)/2-methacryloyloxyethyl phosphorylcholine polymer blend. J Biomed Mater Res Appl Biomater 1998 43(1) 15-20. 

Poly(ethylene terephthalate) (PET) DACRON Dupont Surgical suture membrane, vascular grafts, anterior cruciate ligament prosthesis... 

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