Poly ADP-Ribose Polymerase and Ischemia-Reperfusion Injury

Poly(ADP-Ribose) Polymerase and Ischemia-Reperfusion Injury 

Poly (adenosine 5 -diphosphate ribose) polymerase-1 (PARP-1) [also known as poly (ADP-ribose) synthetase, PARS E.C. 2.4.2.30] is a chromatin-bound enzyme, which is abundantly present in the nuclei of numerous cell types. Single strand breaks in DNA trigger the aaivation of PARP-1, which transfers ADP-ribose moieties from nicotinamide adenine dinucleotide (NAD ) to various nuclear proteins including histones and PARP (automodification domain) itself. This reaaion leads to the generation of nicotinamide, which is an inhibitor (negative feedback) of PARP-1 aaivity. Continuous or excessive activation of PARP-1 (and perhaps other, less well charaaerized members of the PARP enzyme family) produces extended 

Poly(ADP-Ribosyl)ation, edited by Alexander Biirkle. 2006 Landes Bioscience and Springer Science+Business Media. 

Transplantation Vascular diseaso Gonsral anaosihssis Blood loss 

ACUTE TUBULAR NECROSIS (ATN) ACUTE RENAL FAILURE (ARE) 

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