Poloxamer parenteral preparations

It is implicit in the use of parenteral products that a sterile preparation is required. Several methods of sterilization can be used including y-irradiation. However, the influence of y-irradiation on the physico-chemical properties of this poloxamer are not known. The work of Stafford (6) has shown that in the absence of oxygen, aqueous... 

Typical excipients used in parenteral suspensions include surfactants that are used to stabilise emulsions and suspensions as wetting agents (polysorbate 80, poloxamer), as micelle makers for the preparation of solubilisations and to influence the flocculation and deflocculation behaviour of a dispersed system (carmellose sodium, polyvidone). Paren-terally used surfactants in high concentrations are toxic and may cause venous irritation and occasional thrombophlebitis. However, these high concentrations are not necessary to formulate stable parenteral suspensions. 

---