Polar organometallic chemistry reactions

Carbozincations constitute undoubtedly one of the most fascinating fields of organozinc chemistry. Whereas alkenes and alkynes are not traditionally considered as electrophiles in polar organometallic chemistry, carbometallation reactions offer many synthetically... 

Experimental information for synthetic problems in the field of sp2-polar organometallic chemistry can be obtained most efficiently via the Indexes and Chap. II. In many cases, however, this searching procedure does not give a complete solution, so that one has to look for procedures or combinations of procedures that give the best approximation. We shall illustrate the searching procedure with a few examples. In all cases one should read Chap. II before carrying out the derivatization reaction ... 

Most of these catalytic reactions rely on activation steps by which one of the substrates interacts with the metal via Eq. 2.1, in which one of the substrate s covalent bonds is cleaved. This often happens by oxidative addition, one of the key reactions of organometallic chemistry [1]. Oxidative addition mechanisms tend to depend on the polarity of the bond being cleaved, leading to the division of the topic between non-polar bonds in this chapter and polar ones in the next (Chapter 3). 

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