Polar double bonds, asymmetric protonation

ASYMMETRIC PROTONATION OF CARBANIONS AND POLAR DOUBLE BONDS APPLICATION TO TOTAL SYNTHESES... 

However, despite the considerable efforts devoted to address the fundamental issues toward the development of asymmetric protonation, its applications to natural or bioactive synthesis remain sporadic. Herein, two main strategies, namely the enantioselective protonation of metal enolates, especially silicon enolates and the protonation of polar double bonds, i.e., Michael acceptors, were depicted trough the most relevant synthetic applications. These two strategies led to the synthesis of fragrance, natural products, ° bioactive compoundsand... 

Asymmetric Protonation of Carhanions and Polar Double Bonds Application to Total Syntheses... 

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