Points to Learn and Conclusions

The process described herein has a proven track record over some years of reliable and robust commercial manufacturing at a batch size of 100 kg. Its scope is far wider than being restricted only to the current sulfide pyrmetazole, as has been demonstrated in-house in a number of additional examples [24, 25], In fact others have explored this process further on their own substrate sulfides and obtained equally outstanding results [28]. Compared with previously published methods our work has established a new way of effecting an enantioselective sulfide oxidation with the following characteristics  

Also favorable from an atom economy/efEciency perspective [29] the process operates in a really catalytic mode with a turnover number (ton) 4—16 and turnover frequency (tof) 3-12/h. From a logistical point of view the new oxidation was adapted so that it could be linked to an already existing method of preparing the sulfide starting material without requiring any appreciable modifications or re-designs. 

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