Sickle cell anemia point mutations

A. Diseases related to abnormal hemoglobin Sickle cell anemia results from a point mutation (GAG to GTG) that causes valine to replace glutamate at position 6 in the P-globin chain. In hemoglobin Wayne, deletion of a base causes a frameshift that produces the wrong sequence of amino acids in the chain beyond position 127. 

Will Sichel has sickle cell anemia caused by a point mutation in his DNA that changes the sixth amino acid in the p-globin chain of hemoglobin from glutamate to valine. What difference would you expect to find in the chemical bonds formed by these two amino acids ... 

By August 1997, a total of 731 Hb variants had been identified [2] in the almost 50 years after the variant HbS in sickle cell anemia was discovered in 1949. Most Hb variants are caused by a single point mutation resulting in the... 

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