Podophyllum antitumor activity

To obtain the high-pure compounds from the candidate total extracts, column chromatographic separation is performed for some illustrative total extracts. For example, squalene and podophyllotoxin with high purity are isolated from the related extracts. Upon comparison with the LSE, we found that squalene can be easily obtained from the SFE extract than the case of LSE. Although we are not shown here similar interesting results are obtained for other substances. For example, high-purity podophyllotoxin derivatives, which has been known for antitumor activity[4] can be obtained easily from the SFE extract of Podophyllum peltatum. 

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