PLLA based stents

A number of PTMC-based terpolymers have also been studied. Asplund et al. (2006) reported a three-armed P(TMC-co-CL)-PLLA terpolymer as potential stent cover. Random chain scission and homogenous hydrolysis resulted in a loss in mass and molar mass. After 6 weeks of in vitro hydrolysis the molar mass decreased by 54% and the elongation at break dropped from more than 300 to 90%. A medium free cell seeding study showed that endothelial cells adhered well to the polymeric material. Animal study showed very low levels of inflammation, but pronounced neointimal thickening was observed probably due to the premature failure of the material. 

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