Platinum compounds anti-tumour activity

Figure 3.116 Platinum compounds studied for possible anti-tumour activity. I, ris-Dichlorodi-ammineplatinum(II) cisplatin, platinol NSC 119875 neoplatin platinex. II, a.s-Diammine(l,l-cyclobutanedicarboxylato)platinum(II) JM-8 paraplatin NSC 241240. Ill, Oxiplatin. IV, Tetraplatin. V, Amminediacetatodichloro(cyclohexylamine)platinum(IV). VI, cis-Dich oro-trans-dihydroxy-cis-bis(isopropylamine)platinum(IV) iproplatin JM-19 CHIP NSC 256927.

Platinum Compounds with Anti-Tumour Activity.163... 

As cisplatin [(H3N)2PtCl2] developed into a clinically important chemotherapy agent, many inorganic chemists were attracted to the structural similarities of gold(iii) and platinum(ii). Both are d metal ions and form square-planar, four-coordinate structures. Sadler s review of anti-tumour activity by compounds of... 

Figure 3.117 (a) JM-216, a platinum(IV) compound under clinical tests as an orally administered anti-tumour agent (b) the platinum(II) product of in vivo reduction, likely to be the active... 

---