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Platinum antitumour agents

Platinum antitumour agents, 24 (1987) 129 Platelet aggregration, inhibitors of,... [Pg.390]

The mechanism of L-1210 resistance to cisplatin and other platinum antitumour agents remains to be clearly defined. Both Waud [77] and others [78] suggest that reduced cisplatin uptake may be responsible in part for the resistance of the cell line. It has also been found that glutathione levels are high in human ovarian carcinoma cells made resistant to cisplatin in vitro [79]. However, reduction in the level did not alter the resistance to the drug [80]. Decreases in amino-acid transport and changes in amino-acid substrate specificities have also been suggested as the basis for the resistance [81], but definitive evidence has been difficult to obtain. [Pg.139]

See other pages where Platinum antitumour agents is mentioned: [Pg.397]    [Pg.183]    [Pg.349]    [Pg.464]    [Pg.27]    [Pg.129]    [Pg.130]    [Pg.132]    [Pg.132]    [Pg.134]    [Pg.136]    [Pg.138]    [Pg.140]    [Pg.142]    [Pg.144]    [Pg.146]    [Pg.148]    [Pg.150]    [Pg.152]    [Pg.154]    [Pg.156]    [Pg.158]    [Pg.359]    [Pg.585]    [Pg.396]    [Pg.276]    [Pg.104]   
See also in sourсe #XX -- [ Pg.24 , Pg.129 ]

See also in sourсe #XX -- [ Pg.24 , Pg.129 ]

See also in sourсe #XX -- [ Pg.24 , Pg.129 ]



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Antitumour

Antitumour agents

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