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Platelet sialidase

Compounds featuring this typical functionalized cyclopentane unit are the platelet aggregation inhibitor compound (1) of AstraZeneca, the HCV NS3 NS4A protease inhibitor (2) claimed by Tibotec for the treatment of Hepatitis C, and a Neuraminidase (Sialidase) inhibitor (3) discovered by Biocryst for the treatment of influenza (Figure 4.6). Likewise, the widely used nucleoside analog reverse transcriptase inhibitor Abacavir (4), administered against HIV, produced by GlaxoSmithKline, as well as Medivir s beta-secretase 1 (BACE 1) inhibitor (5) for the treatment of Alzheimer s dementia can be probably derived from this hydroformylation protocol. [Pg.333]


See other pages where Platelet sialidase is mentioned: [Pg.216]    [Pg.375]    [Pg.405]    [Pg.417]    [Pg.162]    [Pg.280]    [Pg.324]    [Pg.339]   
See also in sourсe #XX -- [ Pg.324 ]




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