Platelet aggregation staurosporine

In 1990, Isono et al. reported the isolation of RK-286C (318) from the culture filtrate and the mycelium extract of Streptomyces sp. RK-286 (303). In nature, this isolate was obtained in its optically active form [a]p -I- 45.3 (c 0.22, EtOAc). Based on similar CD curves, the absolute configuration of this isolate was assigned to be similar to that of (-E)-staurosporine (295) (see Scheme 2.74) (284). RK-286C has shown PKC inhibitory activity and platelet aggregation in vitro, as well as weak antifungal activity (303). 

RK286c (8) was isolated from Streptomyces sp. AM-2282 and it was fonnd to be a weak inhibitor of PKC compared to staurosporine (1), but it has a comparable platelet aggregation inhibitory activity. Each of staurosporine (1) and (- -)-MLR-52 (9) possesses immunosuppressive activity and reverses mutidrug resistance. ... 

Oka S, Kodama M, Takada H, Tomizuka N, Suzuki H, Agric G. Staurosporine, a potent platelet aggregation inhibitor from a streptomyces species. Biol. Chem. 1986 50 2723-2727. 

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