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Platelet activation dense granules

Serotonin binds to the platelet 5-HTj receptor coupled to PLC via a G protein. The human serotonin receptor has been cloned and have the usual seven transmembrane domain form (Saltzman et al., 1991). Serotonin is rapidly taken up by passive diffusion and by a high affinity eneigy-dependent carrier, and is released upon platelet activation by secretion ftom the dense granules (Pletscher, 1987). [Pg.208]

Some platelet release factors (e.g., serotonin and ADP from dense granules) enhance platelet aggregation on foreign surfaces, while the roles of others (platelet factor 4 with its heparin neutralizing activity (HNA) and P thromboglobulin from a granules) remain to be clarified. [Pg.14]

See other pages where Platelet activation dense granules is mentioned: [Pg.168]    [Pg.607]    [Pg.136]    [Pg.159]    [Pg.236]    [Pg.236]    [Pg.238]    [Pg.243]    [Pg.31]    [Pg.32]    [Pg.33]    [Pg.129]    [Pg.139]    [Pg.166]    [Pg.181]    [Pg.181]    [Pg.181]    [Pg.177]    [Pg.168]    [Pg.39]    [Pg.90]    [Pg.115]    [Pg.189]    [Pg.190]    [Pg.213]    [Pg.318]    [Pg.387]    [Pg.425]    [Pg.425]    [Pg.428]    [Pg.431]    [Pg.432]    [Pg.433]    [Pg.440]    [Pg.534]    [Pg.1589]    [Pg.534]    [Pg.841]    [Pg.32]    [Pg.830]    [Pg.831]    [Pg.48]    [Pg.530]    [Pg.532]    [Pg.110]    [Pg.273]    [Pg.24]    [Pg.190]   
See also in sourсe #XX -- [ Pg.98 , Pg.179 ]



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Platelets activation

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