Plasmalogens acid sensitive

Tkn interesting feature of brain tissue is its considerable content of alkyl- and alkenyl-ether linked PLs indeed, to the present authors knowledge, only spermatozoa possess a comparable significant content of ether lipids [11]. These PLs are detectable with sensitivities comparable to those for diacyl PLs, but with characteristic mass differences (—16 amu compared to the corresponding diacyl-PC). The extreme sensitivity of plasmalogens to even traces of acids is the reason why lyso-Upids are always detectable when TLC separation of brain lipids is performed the acidic groups on the TLC plate (normally unmodified silica gel) are sufficient to induce an unwanted hydrolysis of plasmalogens [134, 135]. 

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