Plasma pseudocholinesterase, drug reaction

Flydrolysis is an important metabolic reaction for drugs whose structures contain ester and amide groups. All types of ester and amide can be metabolized by this route. Ester hydrolysis is often catalysed by specific esterases in the liver, kidney and other tissues as well as non-specific esterases such as acetylcholinesterases and pseudocholinesterases in the plasma. Amide hydrolysis is also catalysed by non-specific esterases in the plasma as well as amidases in the liver. More specific enzyme systems are able to hydrolyse sulphate and glucur-onate conjugates as well as hydrate epoxides, glycosides and other moieties. 

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