Plasma concentration versus time plots intravenous bolus

For example, in Eq. 11.12 (for intravenous bolus), (Cp)o represents the intercept of the plasma concentration versus time profile following the administration of a single dose of a drug. In Eq. 12.13 (for extravascularly administered dose), we can obtain the intercept value from the plasma concentration versus time plot. In both Eqs 11.12 and 12.13, the denominator term is identical (i.e. 1 - For an intravenous bolus, maximum or peak plasma concentration occurs at time 0 and, for an extravascular route, maximum concentration will occur at peak time (Fig. 12.3). 

Figure 4.6 Application of the trapezoidal rule to determine the area under the plasma concentration (Cp) versus time curve (AUC). (Rectilinear plot of plasma or serum concentration versus time following the administration of an intravenous bolus of a drug fitting a one-compartment model.)...

Figure 3.7 Semilogarithmic plot of plasma concentration (Cp) versus time following the administration of a drug as an intravenous bolus. The yaxis intercept yields the initial plasma concentration value (Cp) . K, rate constant.

Figure 3.10 Semilogarithmic plot of plasma concentration (Cp) versus time following administration of the drug prednisolone by intravenous bolus injection. Such a plot permits the determination of the elimination half life (ti/2) and the elimination rate constant (k). (Cp)o, initial plasma concentration.

Figure 11.11 A plot of plasma concentration (Cp) versus time following repetitive intravenous bolus administration of a drug. The figure demonstrates the plasma level resulting from either a series of maintenance doses (dashed line) or an initial loading dose followed by a series of maintenance doses (continuous line), min, minimum max, maximum MTC, minimum toxic concentration MEC, minimum effective concentration t, dosing interval.

Figure 13.1 Typical plasma concentration (Cp) versus time profiles for a drug thatobeysatwo

Figure 13.10 A plasma concentration (Cp) versus time profile for a drug that obeys a two-compartment model following intravenous bolus administration plotted on semilogarithmic paper, p, slow disposition, or post-distribution, rate constant 6, empirical constant 4, apparent volume of distribution for the central compartment /C21, transfer rate constant Xq, administered dose a, distribution rate constant.

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