Plasma concentration versus time plots extravascular route

For example, in Eq. 11.12 (for intravenous bolus), (Cp)o represents the intercept of the plasma concentration versus time profile following the administration of a single dose of a drug. In Eq. 12.13 (for extravascularly administered dose), we can obtain the intercept value from the plasma concentration versus time plot. In both Eqs 11.12 and 12.13, the denominator term is identical (i.e. 1 - For an intravenous bolus, maximum or peak plasma concentration occurs at time 0 and, for an extravascular route, maximum concentration will occur at peak time (Fig. 12.3). 

Figure 1.1 Atypical plot (rectilinear paper) of plasma concentration versus time following the administration of a drug by an extravascular route. MTC, minimum toxic concentration MEC, minimum effective concentration.

Figure 4.8 A semilogarithmic plot of plasma or serum concentration (Cp) versus time following the administration of an identical dose of drug, by an extravascular route, to two subjects with different degree of renal insufficiency.

Figure 7.3 A plot of plasma concentration (Cp) versus time data following the administration of the dose of a drug by two different extravascular routes (or this could be via two different dosage forms and the same extravascular route or two different formulations). 

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See also in sourсe #XX -- [ ]

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