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Plasma biological effect prediction

Disposition and Pharmacokinetics Azathioprine is well absorbed orally and reaches maximum blood levels within 1-2 hours after administration. The tj of azathioprine is 10 minutes, while that of its metabohte 6-mercaptopurine is about an hour. Blood levels have limited predictive value because of extensive metabolism, significant activity of many different metabolites, and high tissue levels attained. Azathioprine and mercaptopurine are moderately bound to plasma proteins and are partially dialyzable. Both are rapidly removed from the blood by oxidation or methylation in the liver and/or erythrocytes. Renal clearance has little impact on biological effectiveness or toxicity, but the dose should be reduced in patients with renal failure. [Pg.915]

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