Plant polyketides

Chalcone Synthase / Stilbene Synthase Family of Plant Polyketide Synthases. 199... [Pg.197]

Chalcone Synthase, a Model Plant Polyketide Synthase. 199... [Pg.197]

CHALCONE SYNTHASE / STILBENE SYNTHASE FAMILY OF PLANT POLYKETIDE SYNTHASES... [Pg.199]

FERRER, J.-L., JEZ, J.M., BOWMAN, M.E., DIXON, R.A., NOEL, J.P., Structure of chalcone synthase and the molecular basis of plant polyketide synthesis, Nature Struct. Biol., 1999,6, 775-784. [Pg.220]

JEZ, J.M., NOEL, J.P., Mechanism of chalcone synthase pKa of the catalytic cysteine and the role of the conserved histidine in a plant polyketide synthase, J. Biol. Chem., 2000, 275, 39640-39646. [Pg.220]

Ferrer, J.-L. et al., Structure of chalcone synthase and the molecular basis of plant polyketide... [Pg.203]

Tropf, S. et al., Reaction mechanisms of homodimeric plant polyketide synthases (stilbenes and chalcone synthase) a single active site for the condensing reaction is sufficient for synthesis of stilbenes, chalcones, and 6 -deoxychalcones. J. Biol. Chem., 270, 7922, 1995. [Pg.203]

Preisig-Mueller, R. et al.. Plant polyketide synthases leading to stilbenoids have a domain catalyzing malonyl-CoA C02 exchange, malonyl-CoA decarboxylation, and covalent enzyme modification and a site for chain lengthening. Biochemistry, 36, 8349, 1997. [Pg.203]

Schroder, J., Plant polyketide synthases a chalcone synthase-type enzyme which performs a condensation reaction with methylmalonyl-CoA in the biosynthesis of C-methylated chalcones. [Pg.1059]

Engineered Biosynthesis of Plant Polyketides Structure-Based and Precursor-Directed Approach... [Pg.45]

Jez JM, Ferrer JL, Bowman ME, Dixon RA, Noel JP (2000) Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry 39 890-902... [Pg.64]

Tropf S, Karcher B, Schroder G, Schroder J (1995) Reaction mechanisms of homodimeric plant polyketide syntahses (stilbene synthase and chalcone synthase). J Biol Chem 270 7922-7928... [Pg.64]

Abe I, Oguro S, Utsumi Y, Sano Y, Noguchi H (2005) Engineered biosynthesis of plant polyketides chain length control in an octaketide-producing plant Type III polyketide synthase. J Am Chem Soc 127 12709-12716... [Pg.65]

Abe I (2008) Engineering of plant polyketide biosynthesis. Chem Pharm Bull 56 1505-1514... [Pg.65]

Abe I, Watanabe T, Morita H, Kohno T, Noguchi H (2006) Engineered biosynthesis of plant polyketides manipulation of chalcone synthase. Org Lett 8 499-502... [Pg.65]

Oguro S, Akashi T, Ayabe S, Noguchi H, Abe I (2004) Probing biosynthesis of plant polyketides with synthetic A-acetylcysteamine thioesters. Biochem Biophys Res Commun 325 561-567... [Pg.66]

Fig. 2a-d. The major architectural paridigms of fatty acid and polyketide synthases. Relationships between genes encoding a bacterial aromatic polyketide synthases, b eukaryotic fatty acid synthases and fungal polyketide synthases, c modular polyketide synthases, and d plant polyketide synthases... [Pg.89]

The two-carbon precursor, acetyl coenzyme A (acetyl-CoA), is the initial substrate for synthesis of the carbon backbone of plant polyketides. As the name implies, polyketides are naturally occurring polymers of ketene (CH2CO) and contain alternating carbonyl and methylene groups derived from the acetate pathway. Polyketides and their derivatives are ubiquitous and are found in all organisms known to produce secondary metabolites. Because of their immense stmctural diversity, a... [Pg.477]

Diketide products of this super family of plant polyketide synthases probably include acridones and also phenylphenalenones such as the aglycone of haemocorin (69), which may be formed from one malonyl-CoA and two phenylpropanyl-CoA units (Figure 8). The proposed derivation of 69 via a diarylheptanoid related to curcumin (70) was... [Pg.270]

Engineered Biosynthesis of Plant Polyketides Chain Length Control in Novel Type III Polyketide Synthases... [Pg.109]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...