Plakortis simplex, plakohypaphorines

Campagnuolo C, Fattorusso E, Taglialatela-Scafati O (2003) Plakohypaphorines A-C, Iodine-Containing Alkaloids from the Caribbean Sponge Plakortis simplex. Eur J Org Chem 284... 

Plakohypaphorins A-F are the first iodinated indolic derivatives from homosclerophorid sponges. They are betaines derived from tryptophan that have been isolated from Plakortis simplex harvested in the Caribbean (Campagnuolo, Fattorusso, and Tagliatela-Scafati, 2003a Borrelli et al., 2004). The antihistaminic activity of these derivatives seems to be related to the number of atoms of iodine, with diiodine derivatives being the most active. 

Borrelli, F., Campagnuolo, C., Capasso, R., Fattomsso, E., and Taglialatella-Scafati, O. (2004) lodinated indole alkaloids from Plakortis simplex new plakohypaphorines and an evaluation of their antihistamine activity. Eur. J. Org. Chem., 3227-3232. 

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