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Pivmecillinam

Frederiksen, E.K. and Godtfredsen, W.O. U.S. Patent 3,660,575 May 2, 1972 assigned to Lovens Kemiske Fabrik Produktionsaktieselskab (Denmark) [Pg.1261]

Chemical Name 6-(((Hexahydro-1 H-azepin-1-yOmethylene] amino) -3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0l heptane-2-carboxylic acid (2,2-dimethyl-1-oxopropoxy)methyl ester [Pg.1261]

Common Name Amdinocillin pivoxil Structural Formula  [Pg.1261]

Trade Name Manufacturer Country Year Introduced [Pg.1261]

The starting material N-formylhexamethyleneimine was prepared from hexamethyleneimine and chloral. [Pg.1261]

Binderup,E.T.,Petersen,H.J,and Liisberg,S. U.S.Patent3,956,279 May 11,1976 assigned to Leo Pharmaceutical Products Ltd. (Denmark) [Pg.1261]

C(,H,C102 18997-19-8) see Pivampicillin Pivmecillinam Raltitrexed l>chIoro-2-methyl-2-propanol... [Pg.2331]

Prednisolone 21 -trimethylacetate pivaloyloxymethyl 6-aminopenicillanate tosylate (CjiHjoNjOgSj 25031-03-2) see Pivmecillinam podophyllotoxin... [Pg.2436]

Fig. 5.2 (Opposite) Examples of the side chain R in various penicillins (the numbers 1-19 correspond to those in Table 5.1). Numbers 20 (mecillinam) and 21 (pivmecillinam) are 6-/3-amidinopenicillanic acids (mecillinams). Number 11 (temocillin) has a methoxy (—OCH3) group at position 6a this confers high /3-lactamase stability on the molecule. Fig. 5.2 (Opposite) Examples of the side chain R in various penicillins (the numbers 1-19 correspond to those in Table 5.1). Numbers 20 (mecillinam) and 21 (pivmecillinam) are 6-/3-amidinopenicillanic acids (mecillinams). Number 11 (temocillin) has a methoxy (—OCH3) group at position 6a this confers high /3-lactamase stability on the molecule.
A 72-year-old woman taking valproate as monotherapy for her epilepsy developed a urinary tract infection and was given pivmecillinam 600 mg/day. During the next few days she became stuporose her serum ammonia concentration was high (113 mmol/1) but liver function was normal. Pivmecillinam and valproate were withdrawn and she recovered rapidly. [Pg.591]

The authors recommended caution when treating patients taking valproate with pivmecillinam because of the risk of hyperammonemic encephalopathy. It seems reasonable... [Pg.591]

Pivmecillinam is not known to be teratogenic but is not recommended in pregnancy because of insufficient safety data. [Pg.161]

Holme E, Greter J, Jacobson CE, Lindstedt S, Nordin I, Kristiansson B, Jodal U. Carnitine deficiency induced by pivampicillin and pivmecillinam therapy. Lancet 1989 2(8661 ) 469-73. [Pg.494]

Nicolle LE, Madsen KS, Debeeck GO, Blochlinger E, Borrild N, Bru JP, Mckinnon C, O Doherty B, Spiegel W, Van Balen FA, Menday P. Three days of pivmecillinam or norfloxacin for treatment of acute uncomplicated urinary infection in women. Scand J Infect Dis 2002 34(7) 487-92. [Pg.2584]

See other pages where Pivmecillinam is mentioned: [Pg.1261]    [Pg.1261]    [Pg.1716]    [Pg.1721]    [Pg.1740]    [Pg.1671]    [Pg.2296]    [Pg.2389]    [Pg.95]    [Pg.95]    [Pg.534]    [Pg.442]    [Pg.443]    [Pg.2794]    [Pg.2794]    [Pg.2795]    [Pg.1671]    [Pg.1671]    [Pg.2296]    [Pg.2389]    [Pg.120]    [Pg.187]    [Pg.220]    [Pg.522]    [Pg.2065]    [Pg.2185]    [Pg.3429]    [Pg.3513]    [Pg.155]    [Pg.155]   
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