Pisiferic acid synthesis enone cyclization

Matsumoto and Usui [8] reported the first total synthesis of ( )-pisiferic acid (1) and ( )-methylpisiferate (3) and this is depicted in Fig. (2). In this synthesis the fundamental skeleton of pisiferic acid has been constructed by the cyclization of enone (9). The introduction of C-10 carboxylic acid in pisiferic acid was accomplished by transannular oxidation. The depicted synthesis has been divided in two parts, Fig. (2) describes the preparation of the alcohol (17) and Fig. (3) deals with the conversion of the alcohol (17) to pisiferic acid (1). 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

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