Pirn kinase inhibitors

Piroxicam-P-cyclodextrin A gastrointestinal safer piroxicam 13CMD2415. Potential use of selective and nonselective Pirn kinase inhibitors for cancer therapy 12JMC8199. 

The synthesis of novel quinoxaline derivatives was key in the study of inhibitors of Pirn kinases. This structure-activity relationship (SAR) study found several promising molecules that demonstrated antiproliferative properties against solid cancer cell lines (PAl, PC3, and DU145). The synthesis of these compounds relied on the previously optimized condensation of diamines with a-halogenated carbonyls followed by oxidation to provide the aromatic bicycle. ... 

In efforts to develop selective inhibitors of the three members of the Pirn kinase family, a high through-put screen (HTS) of functionalized... 

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