Piperidones Knoevenagel reaction

Piperidoius. The Knoevenagel reaction of aryl or heterocyclic aldehydes with ethyl 4-nitrobutanoate in the presence of ammonium acetate has been used for the synthesis of 2-piperidones (equation I). 

Cyanoacetamides yield a-cyanoacrylamides (124) stereoselectively upon reaction with aldehydes and nonselectively with ketones under standard Knoevenagel conditions. a-Cyanoacrylamides (124) are also obtained by partial hydrolysis of methylenemalonodinitriles. With 1,3-diketones, e.g. acetyl-acetone, pyridones like (125) are formed upon reaction with cyanoacetamides. Base-catalyzed dimerization of a-cyanoacrylamides (124) yields piperidones. ... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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