Piperidines 4-aminopiperidine derivatives

More dramatic improvements in SRTD weight inhibition and mortality were achieved by varying the amino substituent at Position 4 while keeping 3,5-dichloroaniline fixed in Position 2. The 4-aminopiperidine derivatives were a particularly fiuitfiil area of investigation. Scheme 2 shows how a variety of substituted piperidines could be readily made fi om a common intermediate. The... 

The piperidine ring is probably the most common heterocycle occurring in pharmaceuticals. Piperidine is often used as a secondary amine in the synthesis of drugs. The local anaesthetic bupivacaine 20 (used as the racemate or the ( S)-enantiomer levobupivacaine) is a pipecolinic acid derivative. The antihistamine bamipine 21 and the analgesic fentanyl 22 are derived from 4-aminopiperidines. The ... 

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