Piperacillin-tazobactam dosage

The indications for penidllin-3-lactamase inhibitor combinations are empirical therapy for infections caused by a wide range of potential pathogens in both immunocompromised and immunocompetent patients and treatment of mixed aerobic and anaerobic infections, such as intra-abdominal infections. Doses are the same as those used for the single agents except that the recommended dosage of piperacillin in the piperacillin-tazobactam combination is 3 g every 6 hours. Adjustments for renal insufficiency are made based on the penicillin component. 

Piperacillin Sodium and Tazobactam Sodium Dosage Recommendations... 

A randomised, crossover study in 9 healthy subjects found that infusions of vancomycin 500 mg and piperacillin 3 g with tazobactam 375 mg had little or no effect on the pharmacokinetics of any of the antibacterials, except that the piperacillin AUC was slightly raised, by about 7%. It was concluded that no dosage adjustments are needed if these drugs are given together. ... 

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