Pinna attenuata

In 1999 Uemuraetal. isolatedattenol A (100) and B (101) (Fig. 1.2.5), both marine natural products exhibiting a moderate cytotoxicity against P388 cells [57], from the Chinese Pinna attenuata. Since they are isomeric triols they differ only in the hydroxyl groups involved in the formation of the ketal functionality, so that this results in a l,6-dioxaspiro[4.5]decane and a 6,8-dioxabicyclo[3.2.1]octane unit as the main structural feature of attenol A and B, respectively. 

A substance designated pinnatoxin was reported to be present in Pinna attenuata from China... 

Pinnatoxins. Mussel toxins from the genus Pinna Pinna attenuata, P. pectinata). These mussels are precious food in the coastal regions of Japan and China and contain varying amounts of P. Poisonings are common but only rarely lethal. The P. are spirocyclic acetals, e.g., P. A C41H61NO, Mr 711,94, [a]n +2.5° (CH,OH), LD99 (mouse i.p.) 180 pg/kg isolated from Pinna muricata see also PSP. 

Attends A (21) and B (22), isolated from the EtOH extract of the Chinese bivalve Pinna attenuata by Uemura et al. [12], exhibited cytotoxicity against P388 cells (IC50 values of 24 and 12 xg/mL, respectively) (Fig. 2). These com-... 

Attenols A and B [83] In 2003, Enders and Lenzen reported the total syntheses of attenols A (109) and B (110) [83], two marine natural products isolated from a bivalve Pinna attenuata [84]. These two compounds, which are distinguishable by their mode of ketalization, both... 

Azaspiracids [azaspiracid-1 (18)] are another class of highly unusual polyketide polyethers originally isolated from Irish mussels that caused azaspiracid shellfish poisoning (5). They are produced by the dinoflagellate Protoperidinium crassipes. A similar class of polyether toxins named pinnatoxins [pinnatoxin A (19)] were reported from the bivalve Pinna pectinata a closely related species P. attenuata is known to cause food poisoning in China. Pinnatoxins are likely of dinoflagellate origin and activate Ca channels (15). 

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